Ca -dependent inhibition of NHE3 requires PKC which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes
نویسندگان
چکیده
Whaseon Lee-Kwon,1,* Jae Ho Kim,1,2,* Jung Woong Choi,1 Kazuya Kawano,1 Boyoung Cha,1 Darlene A. Dartt,3 Driss Zoukhri,3 and Mark Donowitz1 1Department of Medicine, Gastrointestinal Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; 2Division of Physiology, Pusan National University, Pusan, Republic of Korea; and 3The Schepens Eye Research Institute, and Harvard Medical School, Boston, Massachusetts 02114
منابع مشابه
Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes.
The intestinal brush border (BB) Na+/H+ exchanger isoform 3 (NHE3) is acutely inhibited by elevation in the concentration of free intracellular Ca2+ ([Ca2+]i) by the cholinergic agonist carbachol and Ca2+ ionophores in a protein kinase C (PKC)-dependent manner. We previously showed that elevating [Ca2+]i with ionomycin rapidly inhibited NHE3 activity and decreased the amount of NHE3 on the plas...
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Intestinal electroneutral NaCl absorption is mediated by parallel operation of Na(+)/H(+) and Cl(-)/HCO(3)(-) exchange in the enterocyte apical membrane. The ion transporters involved are Na(+)/H(+) exchanger 3 (NHE3) and the down regulated in adenoma (dra) gene product. cAMP-mediated inhibition of NHE3 requires the transporter to bind to the second PDZ (PSD95, disk large, ZO1) domain of the ad...
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